Calcinosis Working Group

Summary of current project(s) of working group:

 

  • “Change in calcinosis over 1 year using the SCTC Radiologic Scoring System for Calcinosis of the hands in patients with Systemic Sclerosis”
  • “Plasma Inorganic Pyrophosphate (PPi) levels as a biomarker for ectopic calcification in scleroderma spectrum and other rheumatic diseases”
  • “Blood levels of Vascular Endothelial Growth Factor (VEGF) and VEGF-induced osteoclast activity in patients with systemic sclerosis with and without calcinosis cutis”
  • "Validation of Mawdsley Questionnaire for calcinosis in patients with Systemic Sclerosis and calcinosis cutis"

Progress to date for working group:

  • Prospective study accepted for publication in Seminars Arthritis and Rheumatism.
  • VEGF project received renewed funding from SCTC (2nd year)

Next steps:

  • To publish the results of the radiographic study
  • To start enrollment of patients for VEGF study
  • To validate the Mawdsley Questionnaire for calcinosis

What are expected deliverables and timelines for grant/working group?

  • Recruitment of SSc patients and healthy controls for VEGF study - December 2021
  • Scoring of all hand XR from validation cohort and analysis of results - October 2021
  • Draft, and final manuscript of SCTC Radiologic Scoring System for Calcinosis study submitted for peer review - December 2021

Publications:

1. Valenzuela A, Baron M, Rodriguez-Reyna TS, et al. Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis [published online ahead of print, 2020 Jun 17]. Semin Arthritis Rheum. 2020;50(5):891-896. doi:10.1016/j.semarthrit.2020.06.007

2. Baron, M., Kahaleh, B., Bernstein, E. J., Chung, L., Clements, P. J., Denton, C… Vacca, A. (2018). An interim report of the Scleroderma Clinical Trials Consortium working groups. Journal of Scleroderma and Related Disorders. https://doi.org/10.1177/2397198318783926

3. Valenzuela A, Baron M, the Canadian Scleroderma Research Group, Herrick A, Proudman S, Stevens W, the Australian Scleroderma Interest Group, Rodriguez-Reyna T, Vacca A, Medsger TA, Fiorentino D, Chung L. Calcinosis is associated with digital ulcers and osteoporosis in patients with Systemic Sclerosis: A Scleroderma Clinical Trials Consortium Study. Semin Arthritis Rheum. 2016 Dec;46(3):344-349. [PMID: 27371996]

4. Chung L, Valenzuela A, Fiorentino D, Stevens K, Li S, Harris J, Hutchinson C, Assassi S, Beretta L, Lakshminarayanan S, Rodriguez-Reyna TS, Denton CP, Taillefer RG, Herrick AL, Baron M; on behalf of the Scleroderma Clinical Trials Consortium Calcinosis Working Group. Validation of a Novel Radiographic Scoring System for Calcinosis Affecting the Hands of Patients with Systemic Sclerosis. Arthritis Care Res (Hoboken). 2014 Aug 22. [PMID: 25155948]

Contact information for how can members get involved:

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