"Evaluating the Role of Vascular Endothelial Growth Factor (VEGF) and VEGF-Induced Osteoclast Activity in the Pathogenesis of Calcinosis in Systemic Sclerosis"

Primary Investigators:
Antonia Valenzuela, MD, MS
Claudia Huerta Calderon

"Development of SCTC Classification Criteria of Systemic Sclerosis Heart Involvement Using Consensus and Multi-Criteria Decision Analysis Methods"

Primary Investigators:
Mandana Nikpour, MBBS, FRACP, FRCPA, PhD
Murray Baron, BBS, MDCM, FRCP(C)
Alessandra Vacca, MD
Laura Ross, MBBS, FRACP

"Development of Preliminary Classification Criteria for Scleroderma Renal Crisis"

Primary Investigators:
Marie Hudson, MD, MPH
Christopher Denton, MD, PhD

"Evaluating the Role of Vascular Endothelial Growth Factor (VEGF) and VEGF-Induced Osteoclast Activity in the Pathogenesis of Calcinosis in Systemic Sclerosis"

Primary Investigator:
Antonia Valenzuela MD, MS

"Synchronizing Systemic Sclerosis Skin Gene Expression and Histology Data with a Machine Learning Approach"

Primary Investigator:
Kimberly Showalter, MD

"Development of Preliminary Classification Criteria for Scleroderma Renal Crisis"

Primary Investigators:
Marie Hudson, MD MPH and Christopher Denton, MD PhD

"Development of a Novel Patient-Reported Outcome Instrument for the Assessment of Digital Ulcers in Systemic Sclerosis"

Primary Investigators:
Michael Hughes, PhD MRCP
John Pauling, PhD FRCP

"Development of a Preliminary Definition of Systemic Sclerosis Heart Involvement"

Primary Investigators:
Mandana Nikpour, MBBS, FRACP, FRCPA, PhD
Murray Baron, BBS, MDCM, FRCP(C)
Dr. Alessandra Vacca

"Plasma Inorganic Pyrophosphate (PPi) Levels as a Biomarker for Ectopic Calcification in Scleroderma Spectrum and Other Rheumatic Diseases"

Primary Investigators:
Dr. Vivien Hsu
Dr. John Varga

"Development and Validation of a Novel Patient-Derived Patient-Reported Outcome Instrument for Assessing the Activity and Impact of Raynaud's Phenomenon in Systemic Sclerosis"

Primary Investigators:
John Pauling, BMedSci, BMBS, PhD, FRCP
Robyn T. Domsic, MD, MPH
Dinesh Khanna, MD, MS

"Development of a Consensus Definition for Scleroderma Renal Crisis (SRC)"

Primary Investigators:
Marie Hudson, MD, MPH
Christopher Denton, MD, PhD

"A Prospective Study to Identify Risk Factors for Progressive Calcinosis in Patients with Systemic Sclerosis: A Scleroderma Clinical Trials Consortium Study"

Primary Investigator:
Lorinda Chung, MD, MS

"Development of a Conceptual Framework for a Novel Patient-Reported Outcome Instrument for the Assessment of Digital Ulcers in Systemic Sclerosis"

Primary Investigators:
Michael Hughes, PhD, MRCP
John Pauling, PhD, FRCP

"The SCTC Damage Index: External Validation in the Canadian Scleroderma Research Group (CSRG) Cohort and Prospective Validation in the INternational SYstemic Sclerosis INception Cohort (INSYNC)"

Primary Investigators:
Mandana Nikpour, MB BS, FRACP, FRCPA, PhD
Murray Baron, BSc, MDCM, FRCP(C)